I know I'm terribly late on this, but still i'm posting here because using ffmpeg in place of hypergrab-x11 was my first intent, but stumbling across this thread i tought it was just not possible, and i've had to search for alternatives (which, for instance, i found, but are far more complicated)
Anyway, it works for me the following way (tried with hypersim)
Code
#Grab at 10fps, source screen is 1920x1080
#output resolution sent to hyperiond is 64x36
source_w=1920 ; source_h=1080
dest_w=64 ; dest_h=36
fps_in=10
sudo rmmod v4l2loopback
sudo modprobe v4l2loopback
sudo v4l2loopback-ctl set-caps "video/x-raw,format=UYVY,width=$dest_w,height=$dest_h" /dev/video0
ffmpeg -re -f x11grab -video_size "$source_w"x"$source_h" -framerate $fps_in -i :0.0 -vf scale=$dest_w:$dest_h:flags=neighbor -pix_fmt uyvy422 -f v4l2 /dev/video0
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